Less transplant-related mortality with variable intensity conditioning than non-myeloablative conditioning in unrelated and related adult allogeneic transplant recipients
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چکیده
منابع مشابه
Reduced intensity conditioning allogeneic transplant for advanced chronic lymphocytic leukemia.
We report the preliminary results of 12 patients with advanced stage chronic lymphocytic leukemia (CLL) transplanted following reduced intensity conditioning (RIC. With a median of 22 months of follow-up, 9 patients are alive and 3 have died of progressive disease, graft-versus-host disease (GVHD) or toxic hepatitis. Acute grade I-III GVHD occurred in 33% of patients and chronic GVHD in 50%. Ei...
متن کاملReduced-intensity conditioning for myeloma: lower nonrelapse mortality but higher relapse rates compared with myeloablative conditioning.
Despite the widespread adoption of reduced-intensity conditioning (RIC) for myeloma, there are few data comparing outcomes with RIC with myeloablative conditioning (MAC). We report the outcomes of patients undergoing allogeneic transplantations for myeloma and reported to the EBMT. A minimum data set was available on 320 RIC and 196 MAC allografts performed between 1998 and 2002. The RIC patien...
متن کاملPentoxifylline did not prevent transplant-related toxicity in 31 consecutive allogeneic bone marrow transplant recipients.
A recent study published by Bianco et all has suggested that pentoxyifylline [3,7-dimethyl-1-(5-oxo-hexyl)-xanthine] reduces morbidity and mortality in patients undergoing bone marrow transplantation (BMT). When compared with a “good risk” control group, pentoxifylline recipients experienced less mucositis (3.7 v 18.7 days,P = .004), less hepaticvenocclusive disease (10% v 65%,P = .001), a lowe...
متن کاملreduced intensity versus full myeloablative conditioning in allogeneic stem cell transplantation for acute myeloid leukemia
introduction: allogeneic hematopoietic stem cell transplantation (hsct) has been reported to be a successful curative treatment in aml patients. myeloablative conditioning (mac) is used more frequent as a preparing regimen. this study attempts to compare the outcome of patients who has received mac and reduced- intensity conditioning (ric). methods: totally, 618 patients with aml underwent hsct...
متن کاملImproved intensive care unit survival for critically ill allogeneic haematopoietic stem cell transplant recipients following reduced intensity conditioning
The use of allogeneic haematopoietic stem cell transplantation (Allo-HSCT) is a standard treatment option for many patients with haematological malignancies. Historically, patients requiring intensive care unit (ICU) admission for transplant-related toxicities have fared extremely poorly, with high ICU mortality rates. Little is known about the impact of reduced intensity Allo-HSCT conditioning...
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ژورنال
عنوان ژورنال: Biology of Blood and Marrow Transplantation
سال: 2005
ISSN: 1083-8791
DOI: 10.1016/j.bbmt.2004.12.098